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More research is needed on how GLP-1 RAs affect electrolyte balance (and it's likely highly individual depending on each person's unique circumstances), but the topic deserves attention given hydrations role in metabolic health
Frequently Asked Questions: GLP-1 Weight Loss Doctors in Rochester, NY Q: What is a GLP-1 weight loss medication and how does it work
In 2010, liraglutide97% homologous to human GLP-1was approved first for diabetes and later for obesity in 2014, while semaglutide, also a modified GLP-1 analogue, now treats both conditions 5
This avoids the catabolic and immunosuppressive effects of cortisol elevation
Pancreatitis: In rare cases, GLP-1 medications have been associated with inflammation of the pancreas
So I slow the cross-taper when coming off high-dose or high-potency D2 blockers, keep the two drugs overlapping longer, and warn patients that the first week or two is the danger window
